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50715

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4-trans-Hydroxyglibenclamide

analytical standard

Synonym(s):

4-trans-OH-glibenclamide, 4-trans-Hydroxycyclohexyl glyburide, 4-trans-Hydroxyglyburide, 5-Chloro-N-[2-[4-[[[[(trans-4-hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide

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About This Item

Empirical Formula (Hill Notation):
C23H28ClN3O6S
CAS Number:
Molecular Weight:
510.00
Beilstein/REAXYS Number:
8398425
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical

format

neat

Storage temp.

−20°C

SMILES string

O=C(NCCC1=CC=C(S(NC(N[C@H]2CC[C@H](O)CC2)=O)(=O)=O)C=C1)C3=CC(Cl)=CC=C3OC

InChI

1S/C23H28ClN3O6S/c1-33-21-11-4-16(24)14-20(21)22(29)25-13-12-15-2-9-19(10-3-15)34(31,32)27-23(30)26-17-5-7-18(28)8-6-17/h2-4,9-11,14,17-18,28H,5-8,12-13H2,1H3,(H,25,29)(H2,26,27,30)/t17-,18-

Inchi Key

IUWSGCQEWOOQDN-IYARVYRRSA-N

Pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Emmie N M Ho et al.
Journal of chromatography. A, 1120(1-2), 38-53 (2006-04-25)
This paper reports two highly efficient liquid chromatography-mass spectrometry (LC-MS) methods for the screening of anabolic steroids, corticosteroids, and acidic drugs for the purpose of doping control in equine sports. Sample extraction was performed using a mixed-mode C8-SCX solid-phase extraction
A Jönsson et al.
European journal of clinical pharmacology, 53(6), 429-435 (1998-04-29)
Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect. With
Emmie N M Ho et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 811(1), 65-73 (2004-10-02)
Anti-diabetics such as sulfonylurea and thiazolidinedione derivatives are hypoglycemic drugs used for the treatment of diabetes. However, they can also be used as a stopper in horseracing. This paper describes a convenient method for the separation and simultaneous detection of
High-performance liquid chromatographic determination of glibenclamide in human plasma and urine
Emilsson HSMI, et al.
Journal of Chromatography. B, Biomedical Applications, 383, 93-102 (1986)
Analytical Profiles of Drug Substances and Excipients
Analytical Profiles of Drug Substances and Excipients, Volume 24 (1981)

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