47170

1-Fluoro-4-nitrobenzene

purum, ≥98.0% (GC)

• Linear Formula: FC₆H₄NO₂
• CAS Number: 350-46-9
• Molecular Weight: 141.10
• Beilstein/REAXYS Number: 606923
• EC Number: 206-502-8
• MDL number: MFCD00007282
• UNSPSC Code: 12352100
• PubChem Substance ID: 329757300

Properties

• vapor density: >1 (vs air)
• vapor pressure: 5.5 mmHg ( 70 °C)
• grade: purum
• assay: ≥98.0% (GC)
• color: deep green-yellow
• refractive index: n20/D 1.531 (lit.)
• bp: 205 °C (lit.)
• mp: 21 °C (lit.)
• density: 1.33 g/mL at 25 °C (lit.)
• SMILES string: [O-][N+](=O)c1ccc(F)cc1
• InChI: 1S/C6H4FNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H
• InChI key: WFQDTOYDVUWQMS-UHFFFAOYSA-N

Description

General description

1-Fluoro-4-nitrobenzene is a fluorinated building block. On reaction with H₂¹⁸O, it affords 4-nitro-1-[¹⁸O]phenol.

Application

1-Fluoro-4-nitrobenzene may be used in the preparation of the following:

• 1-(2-[¹⁸F]fluoroethoxy)-4-nitrobenzene
• 4-[4-[1,1-di[4-(4-aminophenoxy)phenyl]-ethyl]phenoxy]aniline and swelling-agent-modified montmorillonite/PAA (poly(amic acid)
• 1-(4-nitrophenyl)- and 1-(2,4-dinitrophenyl)uracil derivatives
• sulfonaphthoaminophenyl fluorescein (SNAPF), an imaging probe

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302 + H312,H331,H373
• pcodes: P260 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - STOT RE 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: 194.0 °F - closed cup
• flash_point_c: 90 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter