Journal of hazardous materials, 185(2-3), 1348-1354 (2010-11-13)
A novel chelating resin containing cyanoguanidine moiety has been successfully prepared by the functionalizing reaction of a macroporous bead based on chloromethylated copolymer of styrene-divinylbenzene (CMPS) with dicyandiamide (DCDA) in the presence of phase transfer catalyst. The Fourier transform-infrared spectra
A combined ligand and structure-based drug design approach provides a synergistic advantage over either methods performed individually. Present work bestows a good assembly of ligand and structure-based pharmacophore generation concept. Ligand-oriented study was accomplished by employing the HypoGen module of
Chemical communications (Cambridge, England), 47(28), 8124-8126 (2011-06-22)
We report a new synthetic route for preparation of nanoporous carbon nitride fibers with graphitic carbon nitride polymers, by calcination of Al-based porous coordination polymers (Al-PCPs) with dicyandiamide (DCDA) under a nitrogen atmosphere.
Journal of medicinal chemistry, 56(22), 9071-9088 (2013-10-30)
Existing pharmacological inhibitors for nicotinamide phosphoribosyltransferase (NAMPT) are promising therapeutics for treating cancer. By using medicinal and computational chemistry methods, the structure-activity relationship for novel classes of NAMPT inhibitors is described, and the compounds are optimized. Compounds are designed inspired
Investigational new drugs, 29(2), 195-206 (2009-12-05)
In our previous study, a series of novel cyclic cyanoguanidine compounds, eg. 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4- pyrimidinone derivatives have been successfully synthesized and showed remarkable cytotoxicity in several cancer cell lines. In this present study, it is our aim to
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