37019

Atropine

analytical standard

• Synonym(s): Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
• Empirical Formula (Hill Notation): C₁₇H₂₃NO₃
• CAS Number: 51-55-8
• Molecular Weight: 289.37
• Beilstein/REAXYS Number: 91260
• EC Number: 200-104-8
• MDL number: MFCD00022622
• UNSPSC Code: 85151701
• PubChem Substance ID: 329755584
• NACRES: NA.24

Properties

• grade: analytical standard
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): cleaning products; cosmetics; food and beverages; personal care
• format: neat
• storage temp.: −20°C
• SMILES string: CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
• InChI: 1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
• InChI key: RKUNBYITZUJHSG-SPUOUPEWSA-N
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

Description

General description

Atropine is an antimuscarinic drug, which is classified under the tropane alkaloid family of compounds.

Atropine is an antimuscarinic drug, which is classified under the tropane alkaloid family of compounds.
For the analysis of the phytotoxins.

Application

Atropine may be used as a reference standard for the determination of atropine in:

• Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
• Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
• Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
• Plant materials by liquid-liquid extraction and EXtrelut^® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Atropine may be used as a reference standard for the determination of atropine in:

• Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
• Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
• Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
• Plant materials by liquid-liquid extraction and EXtrelut^® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Reconstitution

Dried down, ~100μg/mL after reconstitution with 1 mL of water

Analysis Note

purity : ≥96.0% (HPLC)

Legal Information

Extrelut is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H330
• pcodes: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable