Polychlorinated biphenyls (PCBs) are groups of chemical compounds which are persistent in the environment and are considered highly toxic to humans and animals. PCB No 52 may be used for environmental analysis and precise quality control of food and feed.
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Immunopharmacology and immunotoxicology, 27(4), 601-613 (2006-01-27)
Polychlorinated biphenyls (PCBs) are industrial chemicals that have been released into the environment, resulting in widespread and persistent contamination. PCBs exist as 209 different congeners depending on the chlorine substitution on the biphenyl rings, and the physical properties and toxic
Polychlorinated biphenyls (PCBs) are known to be carcinogenic, but the mechanisms of this action are uncertain. Most, but not all, studies have concluded that PCBs are not directly mutagenic, and that much if not all of the carcinogenic activity resides
Chemical research in toxicology, 24(5), 718-725 (2011-04-13)
The rates of oxidative metabolism of two tetrachlorobiphenyl congeners were determined in hepatic microsomes from four species of sea turtles, green (Chelonia mydas), olive ridley (Lepidochelys olivacea), loggerhead (Caretta caretta), and hawksbill (Eretmochelys imbricata). Hydroxylation of 3,3',4,4'-tetrachlorobiphenyl (PCB 77), an
We analyzed the vapor phase atmospheric concentrations of representative persistent chemicals (i.e., α- and γ-hexachlorocyclohexane, phenanthrene, PCB-18 and PCB-52) in samples collected at a remote site near Eagle Harbor, Michigan, and at an urban site in Chicago, Illinois, using four
Our preceding studies have reported that 2,2',5,5'-tetrachlorobiphenyl (tetraCB)(CB52) is mainly metabolized to 3-hydroxy (OH)-metabolite by phenobarbital (PB)-inducible cytochrome P450 (P450) isoforms such as CYP2B1 and CYP2B18. In this study, the metabolism of CB52 by liver microsomes of untreated and PB-treated
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