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34202

Supelco

Finasteride

VETRANAL®, analytical standard

Synonym(s):

N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, MK-906

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About This Item

Empirical Formula (Hill Notation):
C23H36N2O2
CAS Number:
Molecular Weight:
372.54
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

InChI key

DBEPLOCGEIEOCV-WSBQPABSSA-N

Gene Information

human ... SRD5A2(6716)

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Application

Finasteride may be used as an analytical reference standard for the determination of the analyte in biological fluids[1] and pharmaceutical formulations[2] by high performance liquid chromatography (HPLC) method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Selective 5α-reductase inhibitor; antiandrogen.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Determination of finasteride in tablets by high performance liquid chromatography.
Basavaiah K and Somashekar BC
Journal of Chemistry, 4(1), 109-116 (2007)
High-performance liquid chromatographic determination of finasteride in human plasma using direct injection with column switching.
Takano T and Hata S
Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 141-146 (1996)
Ian M Thompson et al.
The New England journal of medicine, 369(7), 603-610 (2013-08-16)
In the Prostate Cancer Prevention Trial (PCPT), finasteride significantly reduced the risk of prostate cancer but was associated with an increased risk of high-grade disease. With up to 18 years of follow-up, we analyzed rates of survival among all study
Ferenc G Rick et al.
Current opinion in urology, 23(1), 17-24 (2012-12-04)
We provide new viewpoints of hormonal control of benign prostatic hyperplasia (BPH). The latest treatment findings with 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride, refined indications, efficacy, and safety are discussed and compared. We also discuss potential new 5-ARIs and
Marian L Neuhouser et al.
Cancer prevention research (Philadelphia, Pa.), 6(2), 91-99 (2013-01-15)
The role of the insulin-like growth factor (IGF) axis and whether IGFs interact with androgen-suppressing agents in relation to prostate carcinogenesis is unclear. This nested case-control study (n = 1,652 cases/1,543 controls) examined whether serum IGF1, IGF2, IGFBP2, IGFBP3, and

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