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Parbendazole

VETRANAL®, analytical standard

Synonym(s):

Methyl (5-butyl-1H-benzoimidazol-2-yl)carbamate, Methyl 5(6)-butyl-2-benzimidazolecarbamate

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About This Item

Empirical Formula (Hill Notation):
C13H17N3O2
CAS Number:
14255-87-9
Molecular Weight:
247.29
EC Number:
238-133-3
MDL number:
MFCD18910864
UNSPSC Code:
41116107
PubChem Substance ID:
329754214
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCCCc1ccc2nc(NC(=O)OC)[nH]c2c1

InChI

1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17)

InChI key

YRWLZFXJFBZBEY-UHFFFAOYSA-N

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General description

Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK8981
BCCC0411
BCBT1349
SZBF222XV
SZBD267XV

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P Tejada et al.
Veterinary parasitology, 24(3-4), 269-274 (1987-05-01)
Determinations were made of the inhibitory activities of four benzimidazole anthelmintics (Albendazole, Parbendazole, Mebendazole and Thiabendazole) on purified extracts of cytoplasmic and mitochondrial malate dehydrogenase obtained from Ascaris suum, Fasciola hepatica and Moniezia expansa. The highest percentage inhibitions were exhibited
Inhibition of secretion of proteins and triacylglycerol from isolated rat hepatocytes mediated by benzimidazole carbamate antimicrotubule agents.
C R Birkett et al.
Biochemical pharmacology, 30(12), 1629-1633 (1981-06-15)
J C Havercroft et al.
Journal of cell science, 49, 195-204 (1981-06-01)
We have shown that the benzimidazole carbamate, parbendazole, is a potent inhibitor of microtubule assembly in vitro and in vivo. Radiolabelled parbendazole was shown to bind to purified tubulin. Immunofluorescence studies using antitubulin antibody showed that parbendazole effectively depolymerizes cytoplasmic
M Korenaga et al.
Experimental parasitology, 55(3), 358-363 (1983-06-01)
Immunogenicity of adult Strongyloides ratti was studied in rats. Immunization of rats by intraduodenal implantation of adult worms could completely inhibit the egg production and hasten the expulsion of challenged worms which were developed from subcutaneously inoculated L3 or were
D R Hennessy et al.
Journal of veterinary pharmacology and therapeutics, 15(1), 10-18 (1992-03-01)
The effect of intraruminal administration of parbendazole (PBZ) on the flow rate of bile and the pharmacokinetic behaviour of oxfendazole (OFZ) was examined in sheep. PBZ given at 18, 9 and 4.5 mg/kg resulted in a dose-related reduction in bile
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