International journal for parasitology, 39(10), 1099-1108 (2009-03-24)
The tick-borne protozoan parasite Theileria annulata causes a debilitating disease of cattle called Tropical Theileriosis. The parasite predominantly invades bovine macrophages (m phi) and induces host cell transformation by a mechanism that has not been fully elucidated. Infection is associated
The Journal of antimicrobial chemotherapy, 60(4), 802-810 (2007-08-24)
The efficacy of different formulations of the naphthoquinone buparvaquone and two phosphate prodrugs in in vivo models of both visceral and cutaneous leishmaniasis is described. Several topical formulations of buparvaquone containing acceptable excipients were tested in vivo against Leishmania major
Theileriosis is an economically important haemoprotozoal disease with high morbidity and mortality in cattle. Buparvaquone is very effective in the treatment of Theileria infections in cattle. The present study reported an outbreak of bovine tropical theileriosis in Fars Province, southern
Drug development and industrial pharmacy, 36(6), 735-745 (2010-02-09)
The aim of this study was to prepare a lipid-based self-microemulsifying drug delivery system (SMEDDS) to increase the solubility and oral bioavailability of a poorly water-soluble compound, buparvaquone (BPQ). The solubility of BPQ was determined in various vehicles, and pseudo-ternary
Bulletin of environmental contamination and toxicology, 85(2), 116-120 (2010-07-20)
The acute toxicities of five naphthoquinone compounds to Photobacterium phosphoreum were determined. We evaluated the mechanism of toxicity using the structure-activity relationship technique. The results showed that some factors, including the species of substituents, shape/size of molecule and oil-water partition
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