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32144

Supelco

Clinafloxacin

VETRANAL®, analytical standard

Synonym(s):

7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydroxy-4-oxo-3-quinolinecarboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C17H17ClFN3O3
CAS Number:
105956-97-6
Molecular Weight:
365.79
MDL number:
MFCD00865120
UNSPSC Code:
41116107
PubChem Substance ID:
329754065
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

NC1CCN(C1)c2c(F)cc3C(=O)C(=CN(C4CC4)c3c2Cl)C(O)=O

InChI

1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25)

InChI key

QGPKADBNRMWEQR-UHFFFAOYSA-N

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General description

Clinafloxacin is a fluoroquinolone antibiotic with a broad range of bactericidal activity, used in the treatment of gynaecologic and urinary infections. It inhibits bacterial DNA gyrase enzyme which is responsible for synthesis, replication, repair and transcription.

application

Clinafloxacin may be used as a reference standard for the determination of clinafloxacin in urine samples of rat and human by capillary zone electrophoresis.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361d

pcodes

P281

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBV5926

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W Petermann et al.
Scandinavian journal of infectious diseases, 33(11), 832-837 (2002-01-05)
In an open-label, phase 3, randomized, multicenter study, clinafloxacin (200 mg/d) was compared to ceftriaxone (2 g/d; with or without erythromycin) in 527 patients with acute community-acquired bacterial pneumonia (CAP). Primary efficacy parameters were clinical cure rate and microbiologic eradication
Anna Ribera et al.
Diagnostic microbiology and infectious disease, 42(2), 123-128 (2002-02-23)
A total of 33 Stenotrophomonas maltophilia clinical isolates were tested for their susceptibility to clinafloxacin in comparison with ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin, sparfloxacin and trovafloxacin. The MIC(50) and MIC(90) were as follows: ciprofloxacin 4 and 64 microg/mL; clinafoxacin
Satoru Itoh et al.
Mutation research, 520(1-2), 133-139 (2002-09-26)
The skin micronucleus test combined with irradiation due to a sunlight simulator having a spectrum almost identical to solar irradiation was used as a novel in vivo testing method for detecting or comparing the photochemical chromosome damage of quinolone antibacterial
Use of newer quinolones for the treatment of intraabdominal infections: focus on clinafloxacin.
C E Nord
Infection, 27(3), 166-172 (1999-06-23)
Uta Wirnitzer et al.
Mutation research, 609(1), 1-10 (2006-07-11)
Due to the need for in vivo photo-genotoxicity tests, the in vivo photo-comet assay was established in epidermal cells of the SKH-1 mouse. Groups of 10 male SKH-1 mice each were treated once orally with vehicle only, with three fluoroquinolones
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