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N1-[3,5-Bis(trifluoromethyl)benzyl]-N1-methylglycinamide hydrochloride

for GC derivatization, ≥99.0% (HPLC)

Synonym(s):

2-Amino-N-[3,5-bis(trifluoromethyl)benzyl]-N-methylacetamide hydrochloride, AMACE 1

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About This Item

Empirical Formula (Hill Notation):
C12H12F6N2O · HCl
CAS Number:
279682-92-7
Molecular Weight:
350.69
MDL number:
MFCD08277045
UNSPSC Code:
41116105
PubChem Substance ID:
329753330

grade

derivatization grade ((GC derivatization))
for GC derivatization

assay

≥99.0% (HPLC)

form

solid

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

SMILES string

Cl.CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)CN

InChI

1S/C12H12F6N2O.ClH/c1-20(10(21)5-19)6-7-2-8(11(13,14)15)4-9(3-7)12(16,17)18;/h2-4H,5-6,19H2,1H3;1H

InChI key

ZBROHYVGMMPRKP-UHFFFAOYSA-N

General description

N1-[3,5-Bis(trifluoromethyl)benzyl]-N1-methylglycinamide hydrochloride (AMACE 1) is an acylation reagent and is generally used in trace organic analysis.[1]

Other Notes

Nucleophilic derivatizing reagent for the very sensitive trace-organic analysis with GC-ECD-MS[2]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Gang Shao et al.
Journal of chromatography. A, 965(1-2), 233-237 (2002-09-19)
technique that we have termed "bypass HPLC" is introduced as a noncontaminating way to define the retention time of a trace analyte for purification purposes on an HPLC column when the amount of the analyte in real samples is too
R J Lu et al.
Analytical chemistry, 72(8), 1798-1801 (2000-04-28)
Acetamide, 2-amino-N-[[3,5-bis(trifluoromethyl)phenyl]-methyl]-N-methyl-, monohydrochloride, which we have named AMACE1, was synthesized in three steps starting from N-tritylglycine. AMACE1 was coupled via its primary amine group (pKa 8.2) under aqueous conditions to four model analytes for oxidative sugar damage to DNA: glycolate
Gang Shao et al.
Analytical chemistry, 76(11), 3049-3054 (2004-05-29)
As little as 10 pg of standard glycolic acid (glycolate) was detected in a method comprising the following sequence of steps: (1) add glycolate-2,2-d(2) as an internal standard and exchange the carboxylate oxygens in hot HCl/[(18)O]water; (2) form an amide

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