28244
Ethyl cellulose
tested according to Ph. Eur., viscosity 10 mPa.s
Synonym(s):
Ethylcellulosum
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About This Item
agency
USP/NF, tested according to Ph. Eur.
form
coarse powder
autoignition temp.
698 °F
concentration
48.0-49.5% (Ethoxy (OC2H5) groups (dried substances)- EU Portal, GC)
refractive index
n20/D 1.47 (lit.)
viscosity
10 mPa.s
solubility
acetone: soluble, benzene: soluble, butyl acetate: soluble, carbon tetrachloride: soluble, ethanol: soluble, glycerol: insoluble, propylene glycol: insoluble, water: insoluble, xylene: soluble
density
1.14 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
General description
Ethyl cellulose is a lipophilic polymer that possesses excellent membrane-forming ability and durability. It facilitates the formation of free films and is utilized in studying the dynamic interaction of polymer films with water.
Application
Ethyl cellulose has been used in the preparation of biostructures such as matrices, microspheres, microparticles, pellets and tablets for use in drug delivery. It has also been used in making chemically modified ethyl cellulose-based membrane for the purification of IgG.
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Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Anna Jansson et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 20(2), 394-406 (2014-02-26)
Drug release from oral pharmaceutical formulations can be modified by applying a polymeric coating film with controlled mass transport properties. Interaction of the coating film with water may crucially influence its composition and permeability to both water and drug. Understanding
A Martinac et al.
International journal of pharmaceutics, 291(1-2), 69-77 (2005-02-15)
Loratadine-loaded microspheres were prepared by spray-drying of dispersions, emulsions and suspensions differing in polymeric composition and solvents used. Conventional microspheres were obtained by spray-drying of dispersions composed of chitosan (CM) as only polymer, while composed microspheres were obtained by spray-drying
Tetsuya Ozeki et al.
Biological & pharmaceutical bulletin, 35(11), 1926-1931 (2012-11-06)
Production of drug nanoparticles is an effective strategy to enhance solubility and oral absorption of water-insoluble drugs. The handling of drug nanoparticles has been an important issue in drug formulation because nanoparticles easily aggregate each other and redispersion of these