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25745

Sigma-Aldrich

Chloroquine diphosphate salt

≥96.0% (TLC)

Synonym(s):

N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

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About This Item

Empirical Formula (Hill Notation):
C18H26ClN3 · 2H3PO4
CAS Number:
50-63-5
Molecular Weight:
515.86
Beilstein/REAXYS Number:
4223142
EC Number:
200-055-2
MDL number:
MFCD00069852
UNSPSC Code:
12161501

assay

≥96.0% (TLC)

impurities

≤3% water

solubility

H2O: 50 mg/mL, clear

mode of action

enzyme | inhibits

SMILES string

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

InChI key

QKICWELGRMTQCR-UHFFFAOYSA-N

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Other Notes

This product has been replaced by C6628-SIGMA | Chloroquine diphosphate salt solid, ≥98%
Lysosomotropic drug

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D.D. Hong
Anal. Profiles Drug Subst., 5, 61-61 (1976)
[A case of imported vivax malaria in Tomsk].
N P Chernyshova et al.
Meditsinskaia parazitologiia i parazitarnye bolezni, (4)(4), 49-50 (2013-02-27)
Claudia G C Cisneros et al.
Acta dermato-venereologica, 90(2), 175-178 (2010-02-20)
Toxic epidermal necrolysis-like lesions have been described in the setting of lupus erythematosus, and have been considered as a specific hyperacute variant of cutaneous lupus erythematosus, with features different from classical drug-related toxic epidermal necrolysis. We report here a series
Alexander Kreuter et al.
Archives of dermatology, 145(3), 244-248 (2009-03-18)
To determine the efficacy of antimalarial drug use in patients with lupus erythematosus tumidus. Retrospective single-center study. Dermatologic clinic at a university hospital. Thirty-six patients with multifocal lupus erythematosus tumidus. Intervention Treatment with either chloroquine phosphate or hydroxychloroquine sulfate. Cutaneous
Pei-Du Jiang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 64(9), 609-614 (2010-10-05)
Metastatic breast cancers are hard to treat and almost always fatal. Chloroquine diphosphate, a derivative of quinine, has long been used as a potent and commonly used medicine against different human diseases. We therefore investigated the effects of chloroquine diphosphate
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Chromatograms

application for HPLC

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