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17281

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1-(Pentafluoropropionyl)imidazole

derivatization grade (GC derivatization), ≥98.5%

Synonym(s):

PFPI, 1-(Perfluoropropionyl)imidazole

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About This Item

Empirical Formula (Hill Notation):
C6H3F5N2O
CAS Number:
71735-32-5
Molecular Weight:
214.09
EC Number:
275-944-1
MDL number:
MFCD00014502
UNSPSC Code:
41116105
PubChem Substance ID:
329751298
NACRES:
NA.22

grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥98.5% (GC)
≥98.5%

reaction suitability

reagent type: derivatization reagent
reaction type: Esterifications

technique(s)

GC/MS: suitable

refractive index

n20/D 1.399

density

1.4 g/mL at 20 °C (lit.)

storage temp.

−20°C

SMILES string

FC(F)(F)C(F)(F)C(=O)n1ccnc1

InChI

1S/C6H3F5N2O/c7-5(8,6(9,10)11)4(14)13-2-1-12-3-13/h1-3H

InChI key

VZUSRIIEPFQBNE-UHFFFAOYSA-N

General description

Derivatization before a GC analysis helps in yielding distinctive products, which can be achieved using a derivatizing reagent that reacts with amino and hydroxyl functionalities quantitatively.[1] 1-(Pentafluoropropionyl)imidazole (PFPI) is a derivatizing reagent which was found to give high yield of products than pentafluoropropionic anhydride during preparation of methyl ester/pentafluoropropionyl derivatives.[2]

Application

PFPI may be used to incubate the lyophilized samples, for derivatization during GC/MS analysis to measure total d-chiro-Inositol content absorbed by rodents.[3]

Other Notes

Derivatization agent for alcohols and carboxylic acids, etc. in GC[4]
Reagent for methyl ester, pentafluoropropionyl.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

hcodes

H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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F. Karoum et al.
Biomedical Mass Spectrometry, 2, 183-183 (1975)
J.T. Etse et al.
Journal of Natural Products, 51, 314-314 (1988)
F Karoum et al.
British journal of pharmacology, 56(4), 403-411 (1976-04-01)
1 Mass fragmentography was used to measure whole brain concentrations of some of the major metabolites of tyramine, octopamine, dopamine and noradrenaline in acutely treated and in ethanol-dependent rats. 2 Treatments with ethanol, either acutely or chronically, failed to alter
D.R. Knapp
Handbook of Analytical Derivatization Reactions, 208-208 (1979)
Determination of ethanol- and isopropanolamines in air at parts-per-billion levels.
P W Langvardt et al.
Analytical chemistry, 52(4), 669-671 (1980-04-01)
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