12809

O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(tetramethylene)uronium hexafluorophosphate

≥98.0%

• Synonym(s): (Benzotriazol-1-yloxy)dipyrrolidinocarbenium hexafluorophosphate, HBPyU
• Empirical Formula (Hill Notation): C₁₅H₂₀F₆N₅OP
• CAS Number: 105379-24-6
• Molecular Weight: 431.32
• MDL number: MFCD00191770
• UNSPSC Code: 12352101
• PubChem Substance ID: 329749885

Properties

• Quality Level: 100
• assay: ≥98.0%
• form: solid
• reaction suitability: reaction type: Coupling Reactions
• mp: 176 °C (dec.) (lit.)
• solubility: acetonitrile: 0.1 g/mL, clear
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: F[P-](F)(F)(F)(F)F.C1CCN(C1)C(\On2nnc3ccccc23)=[N+]4/CCCC4
• InChI: 1S/C15H20N5O.F6P/c1-2-8-14-13(7-1)16-17-20(14)21-15(18-9-3-4-10-18)19-11-5-6-12-19;1-7(2,3,4,5)6/h1-2,7-8H,3-6,9-12H2;/q+1;-1
• InChI key: XKTRAGMCMJYRRN-UHFFFAOYSA-N

Description

Application

Catalyst for synthesis of dyes

Reagent for peptide coupling

Non-hygroscopic, extremely reactive reagent for peptide coupling giving low racemization. Reaction by-products are non-cytotoxic. Recent studies show that crystal and solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound.

Other Notes

Recent studies show that crystal and solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound[1]; Non-hygroscopic, extremely reactive reagent for peptide coupling giving low racemization. Reaction by-products are non-cytotoxic[2]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves