Journal of chromatography. A, 1203(1), 47-53 (2008-07-25)
The esterification of fatty alcohol ethoxylates (FAEs) with phthalic anhydride in 1,4-dioxane was studied. At 110 degrees C and in the presence of urea, which increased the reaction rate, esterification was completed in 60 min. The reaction yield did not
The Journal of organic chemistry, 74(16), 6368-6370 (2009-07-11)
An efficient enantioselective synthesis of benzyl (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate 2, an essential intermediate for a series of potent CCR2 antagonists, is described. The key step in the sequence is an iodolactamization to yield the highly functionalized (1R,2S,4S,5S)-tert-butyl 2-(benzyloxycarbonylamino)-4-iodo-7-oxo-6-azabicyclo[3.2.1]octane-6-carboxylate 11. An examination of
Copolymers or heteropolymers are large molecules with high molecular weights (>1000 D). They have been underestimated for a long time as to their sensitizing capacities. Allergic contact dermatitis to 6 copolymers in cosmetics and 1 in a medical dressing has
Journal of the American Chemical Society, 130(51), 17226-17227 (2008-12-04)
An intermolecular nickel-catalyzed addition reaction has been developed where phthalic anhydrides react with alkynes to afford substituted isocoumarins. A mechanistic rationale is proposed, implying reductive elimination of Ni(0) promoted by ZnCl(2) cocatalyst as the key step of the catalytic cycle.
Artificial cells, blood substitutes, and immobilization biotechnology, 36(1), 63-73 (2008-02-23)
Agar-gel resin with tryptophan as ligand was synthesized as an adsorbent for the removal of Immunoglobulin E (IgE) in bronchial asthma. Factors affecting the adsorption properties of the adsorbent, such as the different kind of amino acid linked to the
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