Proceedings of the National Academy of Sciences of the United States of America, 108(3), 956-960 (2010-11-12)
Surface functionalization of semiconductors has been the backbone of the newest developments in microelectronics, energy conversion, sensing device design, and many other fields of science and technology. Over a decade ago, the notion of viewing the surface itself as a
Journal of medicinal chemistry, 51(13), 4038-4049 (2008-06-19)
Further exploration of the cycloalkanol ethylamine scaffold, of which venlafaxine ( 1) is a member, was undertaken to develop novel and selective norepinephrine reuptake inhibitors (NRIs) for evaluation in a variety of predictive animal models. These efforts led to the
Trifunctional polymer nanobeads are prepared by destabilization of a mixture of magnetic nanoparticles, quantum dots, and an amphiphilic polymer, followed by functionalization of the bead surface with folic acid molecules. The distribution of the nanoparticles within the nanobeads can be
A series of P1-P3 linked macrocyclic BACE-1 inhibitors containing a hydroxyethylamine (HEA) isostere scaffold has been synthesized. All inhibitors comprise a toluene or N-phenylmethanesulfonamide P2 moiety. Excellent BACE-1 potencies, both in enzymatic and cell-based assays, were observed in this series
Chemical research in toxicology, 22(8), 1447-1453 (2009-07-21)
Certain types of low molecular weight chemicals have the ability to cause respiratory sensitization via haptenation of carrier proteins. It has been suggested that such chemicals must contain multiple "reactive" functional groups to elicit an immune response. In contrast to
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