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07-4820

Sigma-Aldrich

Dimethyl sulfate

SAJ first grade, ≥99.0%

Synonym(s):

Sulfuric acid dimethyl ester

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About This Item

Linear Formula:
(CH3O)2SO2
CAS Number:
77-78-1
Molecular Weight:
126.13
Beilstein/REAXYS Number:
635994
MDL number:
MFCD00008416
UNSPSC Code:
12352108
PubChem Substance ID:
329748447

grade

SAJ first grade

vapor density

4.3 (vs air)

vapor pressure

0.7 mmHg ( 25 °C)

assay

≥99.0%

form

liquid

autoignition temp.

923 °F

availability

available only in Japan

refractive index

n20/D 1.386 (lit.)

bp

188 °C (lit.)

mp

−32 °C (lit.)

density

1.333 g/mL at 25 °C (lit.)

SMILES string

COS(=O)(=O)OC

InChI

1S/C2H6O4S/c1-5-7(3,4)6-2/h1-2H3

InChI key

VAYGXNSJCAHWJZ-UHFFFAOYSA-N

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signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

181.4 °F

flash_point_c

83 °C

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Jie Zheng et al.
Journal of pharmaceutical and biomedical analysis, 50(5), 1054-1059 (2009-07-07)
Dimethyl sulfate (DMS) is an alkylating reagent commonly used in organic syntheses and pharmaceutical manufacturing processes. Due to its potential carcinogenicity, the level of DMS in the API process needs to be carefully monitored. However, in-process testing for DMS is
Cecilia E Ström et al.
Nucleic acids research, 39(8), 3166-3175 (2010-12-25)
Base excision repair (BER) represents the most important repair pathway of endogenous DNA lesions. Initially, a base damage is recognized, excised and a DNA single-strand break (SSB) intermediate forms. The SSB is then ligated, a process that employs proteins also
Yogo Sakakibara et al.
Journal of the American Chemical Society, 133(22), 8396-8399 (2011-05-12)
The movement of the small ribosomal subunit (30S) relative to the large ribosomal subunit (50S) during translation is widely known, but many molecular details and roles of rRNA and proteins in this process are still undefined, especially in solution models.
Muzaffar Khan et al.
Journal of pharmaceutical and biomedical analysis, 58, 27-33 (2011-10-22)
A simple and rapid capillary zone electrophoretic method was developed for determining dimethyl sulfate a possible human carcinogen and mutagen and chloroacetyl chloride a potential genotoxic agent at trace levels in pharmaceutical drug substances by indirect photometric detection. A systematic
G R Hoffmann
Mutation research, 75(1), 63-129 (1980-01-01)
DMS and DES are monofunctional alkylating agents that have been shown to induce mutations, chromosomal aberrations, and other genetic alterations in a diversity of organisms. They have also been shown to be carcinogenic in animals. As an alkylating agent, DMS
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