MABS731
Anti-PON1, clone EPR2893, Rabbit Monoclonal Antibody
clone EPR2893, from rabbit
Synonym(s):
Serum paraoxonase/arylesterase 1, PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
antibody form
unpurified
antibody product type
primary antibodies
clone
EPR2893, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PON1(5444)
General description
Serum paraoxonase/arylesterase 1 (PON 1), also known as Aromatic esterase 1 (A-esterase 1) or K-45 or Serum aryldialkylphosphatase 1, and encoded by the gene name PON1 or PON, is an esterase and lactonase that is synthesized in the liver and secreted into blood, associated exclusively with high density lipoproteins that belongs to the paraoxonase family. PON1 hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. This protein has been implicated in protection from atherosclerosis. PON 1 possesses both antioxidant and anti-inflammatory properties. Protecting LDL and HDL from lipid peroxidation, PON 1 degrades specific oxidized cholesteryl esters and oxidized phospholipids contained in lipoproteins. PON1 is expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. Mutations in PON1 have been associated with Microvascular complications of diabetes 5.
Immunogen
Synthetic peptide corresponding to human PON1.
Application
Produced in collaboration with Epitomics
Research Category
Signaling
Signaling
Research Sub Category
Developmental Signaling
Developmental Signaling
This Anti-PON1, clone EPR2893, Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of PON1.
Quality
Evaluated by Western Blotting in human fetal kidney, human ovary cancer, human fetal liver, and human plasma lysates.
Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected PON1 in human fetal kidney, human ovary cancer, human fetal liver, and human plasma lysates.
Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected PON1 in human fetal kidney, human ovary cancer, human fetal liver, and human plasma lysates.
Target description
~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physical form
Format: Unpurified
Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
Unpurified
Storage and Stability
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
Certificates of Analysis (COA)
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