MABN1100

Anti-REG1A, clone 1A4 Antibody

ascites fluid, clone 1A4, from rabbit

• Synonym(s): Lithostathine-1-alpha, Islet cells regeneration factor, ICRF, Islet of Langerhans regenerating protein, REG, Pancreatic stone protein, PSP, Pancreatic thread protein, PTP, Regenerating islet-derived protein 1-alpha, REG-1-alpha, Regenerating protein I al
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• antibody form: ascites fluid
• antibody product type: primary antibodies
• clone: 1A4, monoclonal
• species reactivity: human
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable
• isotype: IgG1
• UniProt accession no.: P05451
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... REG1A(5967)

Description

General description

Lithostathine-1-alpha, also known as Islet cells regeneration factor (ICRF) or Islet of Langerhans regenerating protein (REG) or Pancreatic stone protein (PSP) or Pancreatic thread protein (PTP) or Regenerating islet-derived protein 1-alpha (REG-1-alpha), and encoded by the gene name REG1A or PSPS or PSPS1 or REG is a member of the Reg family of secreted proteins with a C-type lectin domain. REG1A is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Due to variable glycosylation, pancreatic REG1A exists as multiple species of 16 - 18 kDa. REG1A promotes the maintenance and growth of pancreatic islet β-cells and intestinal villi and is upregulated in pancreatitis and some carcinomas. REG1A is an antigenic target in autoimmune diabetes.

Immunogen

Purified recombinant fragment of human REG1A fused with HlgGFc-tag expressed in HEK293 cells.

Application

Detect REG1A using this Anti-REG1A, clone 1A4 Antibody validated for use in IHC & immunofluorescence.

Immunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected REG1A in PC12 cells.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Quality

Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected REG1A in human pancreas tissue.

Target description

19 kDa calculated

Physical form

Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.

Unpurified

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable