C-reactive protein (UniProt P02741) is encoded by the CRP (also known as PTX1) gene (Gene ID 1401) in human. CRP is the classical acute phase reactant produced by the liver and its circulating concentration increases rapidly in a cytokine-mediated response to tissue injury, infection, and inflammation. It is an annular, pentameric protein that binds to lysophosphatidylcholine expressed on the surface of dead or dying cells and bacteria in order to activate the complement system via the C1Q complex. Interleukin-6 (IL-6), produced by macrophages in response to injury and infection, is a major trigger for the synthesis of CRP by the liver. It plays a major role in early host defense by promoting agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine. It can also interact with DNA and histones and scavenge nuclear material released from damaged circulating cells.
Specificity
Clone 2A8.1 targets an epitope within the C-terminal half of human C-reactive protein.
Immunogen
GST-tagged recombinant human C-reactive protein C-terminal fragment.
Application
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected C-reactive protein in human cerebral cortex, kidney, and liver tissue sections.
This mouse monoclonal Anti-C-Reactive Protein, clone 2A8.1 Antibody, Cat. No. MABF1070 is validated for use in Western Blotting and Immunohistochemistry (Paraffin), for the detection of C-Reactive protein.
Quality
Evaluated by Western Blotting in human liver tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected C-reactive protein in 10 µg of human liver tissue lysate.
Target description
~25 kDa observed. 25.04/23.05 kDa (with/without signal peptide a.a. 1-18 sequence) calculated. Uncharacterized bands may be observed in some lysate(s).
Physical form
Format: Purified
Other Notes
Concentration: Please refer to lot specific datasheet.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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In patients with invasive fungal diseases, there is often little cellular inflammatory response. We tested the idea that binding of the human constitutive plasma protein serum amyloid P component (SAP) (also called PTX2) to Candida albicans dampens the innate immune
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