B-cell lymphoma/leukemia 11B, also known as B-cell lymphoma/leukemia 11B (BCL-11B), B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, and encoded by the gene name BCL11B/ CTIP2/ RIT1, is a tumor-suppressor protein involved in t-cell lymphomas. B-cell lymphoma/leukemia 11B have been shown to play a role in the p53-signaling pathway. B-cell lymphoma/leukemia 11B may be a key regulator of both differentiation and survival during thymocyte development. B-cell lymphoma/leukemia 11B represses transcription through direct, tfcoup2-independent binding to a gc-rich response element. B-cell lymphoma/leukemia 11B interacts with tfcoup1, sirt1, arp1 and ear2. B-cell lymphoma/leukemia 11B is highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
Immunogen
GST-tagged recombinant protein corresponding to human B-cell lymphoma/leukemia 11B.
Application
Anti-B-cell lymphoma/leukemia 11B, clone 3A8.2 is an antibody against B-cell lymphoma/leukemia 11B for use in WB, ICC.
Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected B-cell lymphoma/leukemia 11B in Jurkat cells.
Research Category Epigenetics & Nuclear Function
Research Sub Category Nuclear Receptors
Quality
Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected B-cell lymphoma/leukemia 11B in 10 µg of Jurkat cell lysate.
Target description
~94 and ~86 kDa observed
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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