40S ribosomal protein S27, also known as Metallopan-stimulin 1 (MPS-1), and encoded by the gene name MPS1 or RPS27, belongs to the ribosomal protein S27e family. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. MPS-1 is a component of the 40S subunit and contains a C4-type zinc finger domain that can bind to zinc. MPS-1 is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that MPS-1 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3.
Immunogen
Purified recombinant fragment of human MPS-1 expressed in E. Coli
Application
Anti-MPS-1, clone 4A12 Antibody detects level of MPS-1 & has been published & validated for use in MPS-1.
Research Category Epigenetics & Nuclear Function
Research Sub Category RNA Metabolism & Binding Proteins
Quality
Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected MPS-1 in human lung cancer and brain tissues.
Target description
9 kDa calculated
Physical form
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Unpurified
Storage and Stability
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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The X-linked deubiquitinase, USP9X, is implicated in multiple cancers by targeting various substrates. Increased expression of USP9X is observed in non-small-cell lung cancer (NSCLC) and is correlated with poor prognosis. However, the molecular mechanism for USP9X regulation of tumor cell
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