MABC777

Anti-ING1, clone EPR6788, Rabbit Monoclonal Antibody

clone EPR6788, from rabbit

• Synonym(s): Inhibitor of growth protein 1
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• antibody form: unpurified
• antibody product type: primary antibodies
• clone: EPR6788, monoclonal
• species reactivity: rat, mouse, human
• technique(s): flow cytometry: suitable; western blot: suitable
• isotype: IgG
• UniProt accession no.: Q9UK53
• shipped in: wet ice
• Gene Information: human ... ING1(3621)

Description

General description

Inhibitor of growth protein 1 (ING1) is a tumor suppressor protein that can induce cell growth arrest and apoptosis. It is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. ING1 is localized to the nucleus. Reduced expression of ING1 has been detected in various cancers including Squamous cell carcinoma of the head and neck.

Immunogen

Synthetic peptide corresponding to human ING1.

Application

Flow Cytometry Analysis: A 1:10-100 dilution from a representative lot detected ING1 in permeabilised NIH/3T3cells.

Produced in collaboration with Epitomics

Research Category
Apoptosis & Cancer

Research Sub Category
Tumor Markers

This Anti-ING1, clone EPR6788, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of ING1.

Quality

Evaluated by Western Blotting in HepG2, HeLa, MCF-7, Jurkat, C6, RAW264.7, PC-12, and NIH/3T3 cell lysates.

Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected ING1 in HepG2, HeLa, MCF-7, Jurkat, C6, RAW264.7, PC-12, and NIH/3T3 cell lysates.

Target description

~47 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Format: Unpurified

Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

Unpurified

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2