Ephrin type-B receptor 6, also known as HEP or Tyrosine-protein kinase-defective receptor EPH-6, and encoded by the gene name EPHB6, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Eph receptors and ephrin ligands are membrane-bound cell-cell communication molecules with well-defined functions in development. EPHB6 is a unique member in the Eph family of receptor tyrosine kinases in that its kinase domain contains several alterations in conserved amino acids and is catalytically inactive. EPHB6 is expressed in brain and pancreas with lower levels found in heart, placenta, lung, liver, skeletal muscle, and kidney. EPHB6 can both positively and negatively regulate cell adhesion and migration and tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition.
Immunogen
Purified recombinant fragment of human EphB6 expressed in E. Coli
Application
Detect EPHB6 using this Anti-EPHB6, clone 8E7H12 Antibody validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:200-1:1,000 dilution from a representative lot detected EPHB6 in human bladder carcinoma tissue.
Research Category Apoptosis & Cancer
Research Sub Category Tumor Markers
Quality
Evaluated by Western Blotting in Jurkat and NIH/3T3 cell lysates.
Western Blotting Analysis: A 1:500-1:2,000 dilution of this antibody detected EPHB6 in Jurkat and NIH/3T3 cell lysates.
Target description
~120 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1 in buffer containing PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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