MABC154

Anti-RRM2 Antibody, clone 4D1.2

clone 4D1.2, from mouse

• Synonym(s): Ribonucleoside-diphosphate reductase subunit M2, Ribonucleotide reductase small chain, Ribonucleotide reductase small subunit
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: mouse
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 4D1.2, monoclonal
• species reactivity: human
• technique(s): immunocytochemistry: suitable; western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_001025
• UniProt accession no.: P31350
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... RRM2(6241)

Description

General description

Ribonucleoside-diphosphate reductase subunit M2 (RRM2) is a cytoplasmic protein, which catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates, and plays an important role in DNA damage and repair. RRM2 has been implicated in various types of cancer.

Immunogen

GST-tagged recombinant protein corresponding to human RRM2.

Application

Detect Ribonucleotide Reductase using this mouse monoclonal antibody, Anti-RRM2 Antibody, clone 4D1.2 validated for use in western blotting & ICC.

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected RRM2 in HepG2 and A431 cells.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Quality

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected RRM2 in 10 µg of HeLa cell lysate.

Target description

~45 kDa observed

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
HeLa cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable