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MAB5354

Sigma-Aldrich

Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1

clone 4.1, Chemicon®, from mouse

Synonym(s):

Anti-AAA, Anti-ABETA, Anti-ABPP, Anti-AD1, Anti-APPI, Anti-CTFgamma, Anti-CVAP, Anti-PN-II, Anti-PN2, Anti-alpha-sAPP, Anti-preA4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4.1, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000484.2
NM_201413.1
NM_201414.1

UniProt accession no.

P05067

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... APP(351)

Specificity

Amyloid-beta Precursor Protein, KPI (Kunitz protease inhibitor) domain. The antibody reacts with both native and recombinant protein. The antibody has been shown to partially inhibit protease inhibitory properties.

Immunogen

Epitope: KPI domain
Purified recombinant KPI domain of Amyloid-beta precursor protein.

Application

Anti-Amyloid β Precursor Protein Antibody, KPI domain, clone 4.1 detects level of Amyloid β Precursor Protein & has been published & validated for use in ELISA, WB, IH.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot: 2-5 μg/mL using ECL on human brain or platelets. Recognizes a protein of 100-120 kDa.

Immunohistochemistry: 2-5 μg/mL on frozen tissue sections.

ELISA: 1 μg/mL in a direct assay and 10 μg/mL in an indirect assay.

Optimal working dilutions must be determined by the end user.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 20 mM Sodium phosphate buffer with 150 mM NaCl.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 6 months of date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-? production.
Bordji, K; Becerril-Ortega, J; Nicole, O; Buisson, A
The Journal of Neuroscience null
Jochen Winterer et al.
Cell reports, 19(6), 1110-1116 (2017-05-13)
The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on

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