UTF1 is a transcription factor that was originally identified due to its expression in Embryonic Stem (ES) cells, Embryonic Carcinoma (EC) cells, and germ line tissues. Expression was not found in adult tissues. It was thought at the time that UTF1 might play an important role in early molecular events of embryogenesis. Subsequent studies have shown that UTF1 is a target of the Oct-4 / Sox-2 complex, a key determinant of pluripotency in stem cells
Immunogen
Recombinant GST Fusion protein, human UTF-1
Application
Anti-UTF-1 Antibody, clone 5G10.2 detects level of UTF-1 & has been published & validated for use in ELISA, WB & IC.
Physical form
Format: Purified
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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The aim of this study was to elucidate the molecular status of single human adult germ stem cells (haGSCs) and haGSC colonies, which spontaneously developed from the CD49f MACS and matrix- (collagen-/laminin+ binding-) selected fraction of enriched spermatogonia. Single-cell transcriptional
Human reproduction (Oxford, England), 34(6), 966-977 (2019-05-22)
Is it feasible to disseminate testicular tissue cryopreservation with a standardized protocol through a coordinated network of centers and provide centralized processing/freezing for centers that do not have those capabilities? Centralized processing and freezing of testicular tissue from multiple sites
Undifferentiated embryonic cell transcription factor-1 (UTF1) is an important transcription factor during development, which plays critical roles in cell fate determination. However, its expression and function in somatic tissues remain unclear. Here, we investigated the expression pattern of the UTF1
Fertility and sterility, 102(2), 566-580 (2014-06-04)
To determine the molecular characteristics of human spermatogonia and optimize methods to enrich spermatogonial stem cells (SSCs). Laboratory study using human tissues. Research institute. Healthy adult human testicular tissue. Human testicular tissue was fixed or digested with enzymes to produce
Human spermatogonial stem cells (SSCs) are an essential source to maintain spermatogenesis as an efficient process for daily sperm production with high self-renewal capacity along adulthood. However, the phenotype and the subpopulation that represent the real reserve SSC for the
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