HKI3MAG-99K

MILLIPLEX^® Human Kidney Injury Magnetic Bead Panel 3 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: β-2-Microglobulin (β2M), Retinol Binding Protein 4 (RBP4), Uromodulin.

• UNSPSC Code: 12161503
• eCl@ss: 32161000

Properties

• species reactivity: human
• manufacturer/tradename: Milliplex^®
• assay range: accuracy: 100-103%; sensitivity: 0.052-0.175 ng/mL; (MinDC = 2SD); standard curve range: 0.05-50 ng/mL; (RBP4); standard curve range: 0.10-100 ng/mL; (β-2-Microglobulin); standard curve range: 0.10-100 ng/mL; (Uromodulin); inter-assay cv: <15%; intra-assay cv: <10%
• technique(s): multiplexing: suitable
• detection method: fluorometric (Luminex xMAP)
• shipped in: wet ice

Description

General description

Maintenance of physiological balance in the body is attributed in part to normal kidney function. Altered kidney function due to injury, drug toxicity or kidney failure may be life threatening. Toxicity is the leading cause of drug failure, so research is expanding in search of more sensitive, rapid methods to determine organ-specific damage as quickly as possible. Traditionally, blood urea nitrogen (BUN) and serum creatinine tests have been used to determine drug-induced damage to the kidney. These tests only detect kidney damage after it begins and do not allow for the elucidation of where in the kidney the damage has occurred. Specificity and earlier detection of kidney injury is vital, and this area of research is expanding in search of more sensitive, rapid methods for determining the specific area of damage in kidney.

The MILLIPLEX^® portfolio provides valuable research assays to investigate multiple biomarkers of kidney injury in human urine samples using the Luminex^® xMAP^® instrument platform. The analytes available for this multiplex kit are: β-2-Microglobulin (β2M), Retinol Binding Protein 4 (RBP4), Uromodulin.

Panel Type: Toxicity

Application

• Analytes: β-2-Microglobulin, RBP4, Uromodulin
• Recommended Sample type:
• Recommended Sample dilution: 1:500 in kit Assay Buffer. Customers need to determine the optimal dilution factor for their samples. Our recommendations are based on urine samples from normal subjects.
• Assay Run Time: Overnight

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Other Notes

Sensitivity: Please see kit protocol for individual assay sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Safety Information

• pictograms: GHS06,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H302 + H332,H311,H317,H318,H373,H411
• pcodes: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• target_organs: Respiratory Tract
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects