The antibody datasheet indicates that the antibody was not tested against the different isoforms of IL-18. The capture antibody is a monoclonal mouse anti-Human IL-18 antibody, and the immunogen used is recombinant Human IL-18. However, it was not tested for cross-reactivity with the pro-form.
HIL18MAG-66K
MILLIPLEX® Human IL-18 Singleplex Magnetic Bead Kit
Synonym(s):
Magnetic bead assay
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
$725.00
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General description
“Cytokine” is a general term used for a diverse group of soluble proteins and peptides which act as regulators under both normal and pathological conditions to modulate the functional activities of individual cells and tissues. These proteins also mediate direct interactions between cells and regulate processes taking place in the extracellular environment. Cytokines differ from hormones in that they act on a wider spectrum of target cells. Also, unlike hormones, they are not produced by specialized cells which are organized in specialized glands. The cytokine group of proteins includes lymphokines, interferons, colony stimulating factors and chemokines. Cytokine and chemokine research plays a significant role in achieving a deeper understanding of the immune system and its multi-faceted response to most antigens, as well as disease states such as inflammatory disease, allergic reactions, irritable bowel disease (IBD), sepsis, and cancer.
The MILLIPLEX® Human IL-18 Singleplex enables you to focus on the therapeutic potential of IL-18 as well as the modulation of IL-18 expression.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
The MILLIPLEX® Human IL-18 Singleplex enables you to focus on the therapeutic potential of IL-18 as well as the modulation of IL-18 expression.
The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.
Panel Type: Cytokines/Chemokines
Application
- Analyte: IL-18
- Recommended Sample type: Serum, plasma, tissue culture supernatant
- Recommended Sample dilution: Neat serum and plasma. Tissue culture supernatant may require a dilution with an appropriate control medium prior to assay.
- Assay Run Time: Overnight or two-hour primary incubation. For best results, an overnight incubation is recommended.
- Research Category: Inflammation & Immunology
- Research Subcategory: Obesity, Metabolic Disorders, Inflammation & Autoimmune Mechanisms
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
target_organs
Respiratory Tract
Storage Class
10 - Combustible liquids
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Are the antibodies in the human IL-18 singleplex kit (HIL18MAG-66K) specific to the mature form of IL-18, and is there information on their cross-reactivity with pro-IL18?
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