GF342
LIF,
Human Recombinant Animal Free
Synonym(s):
Leukemia Inhibitory Factor, Emfilermin, MLPLI, HILDA, D-FACTOR
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75
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General description
LIF is a pleiotrophic factor produced by multiple cell types including T cells, myelomoncytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor.
Recombinant human LIF is a 19.6 kDa protein containing 180 amino acids residues including three disulfide bonds.
Recombinant human LIF is a 19.6 kDa protein containing 180 amino acids residues including three disulfide bonds.
Quality
Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤0.1 ng/ml, corresponding to a specific activity of ≥1 x 10^7 units/mg.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Lizhao Feng et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(23), 2002155-2002155 (2020-12-12)
Canavan disease (CD) is a fatal leukodystrophy caused by mutation of the aspartoacylase (ASPA) gene, which leads to deficiency in ASPA activity, accumulation of the substrate N-acetyl-L-aspartate (NAA), demyelination, and spongy degeneration of the brain. There is neither a cure
Articles
Leukemia Inhibitory Factor (LIF) is a stem cell growth factor used for the in vitro culture of pluripotent mouse embryonic stem cells (ES cells).
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