The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). GTAP is a member of the E2 ubiquitin-conjugating enzyme family. GTAP may participate in intercellular adhesion and embryonic development. GTAP is thought to play a role in stem cell development via its regulation of laminin-dependent embryonic cell adhesion and the formation of embryoid bodies.
Immunogen
A synthetic peptide corresponding to amino acids 7-22 (QGQQQPGPGQQLGGQG) of human GTAP, conjugated to KLH.
Human
Application
Immunoblotting (3-10 g/ml)
Warning
Toxicity: Regulatory Review (Z)
Physical form
In PBS.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Due to a high degree of sequence identity, this antibody is also expected to react with mouse and rat GTAP. Antibody should be titrated for optimal results in individual systems.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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