ABN488

Anti-SRPX2 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Sushi-repeat-containing protein X-link 2, BPP, CBPS, PMGX, SRPUL
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human, rat
• technique(s): immunohistochemistry: suitable; western blot: suitable
• UniProt accession no.: O60687
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... SRPX2(27286)

Description

General description

Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene associated with the speech and language centers of the human brain. SRPX2 mutations can lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. SRPX2 has been shown to mediate angiogenesis and acts as a ligand for the urokinase-type plasminogen activator, which facilitates invasive migration of sprouting endothelial cells. SRPX2 is highly expressed in brain, neurons, placenta, lung, trachea, uterus and adrenal gland; and weakly expressed in the peripheral blood, brain and bone marrow. SRPX2 is also expressed in numerous cancer cell lines, including overexpressed in gastric cancer, increasing phosphorylation levels of focal adhesion kinase, and enhanced cellular migration and adhesion, indicating that SRPX2 may be a useful target in the treatment of metastatic cancers.

Immunogen

KLH-conjugated linear peptide corresponding to human SRPX2.

Application

Anti-SRPX2 Antibody is a highly specific rabbit polyclonal antibody, that targets Sushi-repeat-containing protein X-linked 2 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SRPX2 in rat lung tissue.

Research Category
Neuroscience

Research Sub Category
Sensory & PNS

Quality

Evaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected SRPX2 in 15 µg of human lung tissue lysate.

Target description

~55 kDa observed. Uncharacterized bands may appear in some lysate(s).

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human lung tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable