ABN469
Anti-DISC1 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
DISC1 Antibody, Disrupted in schizophrenia 1 protein, KIAA0457
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
species reactivity (predicted by homology)
human (based on 100% sequence homology)
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... DISC1(27185)
General description
Disrupted in schizophrenia 1 protein (DISC1) is involved in the regulation of multiple aspects of embryonic and adult neurogenesis. DISC1 may play a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. DISC1 is shown to inhibit the activation of AKT-mTOR signaling upon interaction with CCDC88A. DISC1 is required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Additionally, DISC1 is suggested to regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. DISC1 has been shown to participates in the Wnt-mediated neural progenitor proliferation as a positive regulator and may have a role, together with PCNT, in the microtubule network formation.
DICS1 is highly expressed in the dentate gyrus of the hippocampus. It is also expressed in the temporal and parahippocampal cortices and cells of the white matter. Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa.
DICS1 is highly expressed in the dentate gyrus of the hippocampus. It is also expressed in the temporal and parahippocampal cortices and cells of the white matter. Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa.
Specificity
This antibody recognizes the N-terminus of DISC1.
Immunogen
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human DISC1.
Application
Anti-DISC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Disc1 & has been tested in western blotting.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
Quality
Evaluated by Western Blotting in NIH/3T3 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected DISC1 in 15 µg of NIH/3T3 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected DISC1 in 15 µg of NIH/3T3 cell lysate.
Target description
~95 kDa observed. Uncharacterized bands may appear in some lysates. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
NIH/3T3 cell lysate
NIH/3T3 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificates of Analysis (COA)
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Johanna Heider et al.
BMC neuroscience, 25(1), 12-12 (2024-03-05)
Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previous studies have mainly used
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