SLIT and NTRK-like family 3 (Slitrk3) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Overexpression of Slitrk3 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.
Specificity
This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
Immunogen
KLH-conjugated linear peptide corresponding to human Slitrk3.
Application
Immunohistochemistry Analysis: Human brain tissue was prepared using heat-induced epitope retrieval (HIER). Immunostaining was performed using 2.5 µg/mL Slitrk3 antibody.
Research Category Neuroscience
Neuroscience
Research Sub Category Developmental Neuroscience
Neurofilament & Neuron Metabolism
This Slitrk3 antibody is validated for use in WB & IHC for the detection of the Slitrk3 protein.
Quality
Evaluated by Western Blot in SK-N-SH cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Slitrk3 in 15 µg of SK-N-SH cell lysate.
Target description
~120 kDa observed
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control SK-N-SH cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Frontiers in molecular neuroscience, 12, 213-213 (2019-09-26)
Single-passing transmembrane protein, Slitrk3 (Slit and Trk-like family member 3, ST3), is a synaptic cell adhesion molecule highly expressed at inhibitory synapses. Recent studies have shown that ST3, through its extracellular domain, selectively regulates inhibitory synapse development via the trans-synaptic
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