AB5603A4
Anti-Sox2, Alexa Fluor™ 488 Conjugate Antibody
from rabbit, ALEXA FLUOR™ 488
Synonym(s):
Transcription factor SOX-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
ALEXA FLUOR™ 488
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SOX2(6657)
General description
SOX2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution.
Immunogen
Synthetic peptide from human Sox2.
Application
Detect Sox2 using this Anti-Sox2, Alexa Fluor 488 Conjugate Antibody validated for use in ICC.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Transcription Factors
Transcription Factors
Quality
Evaluated by Immunocytochemistry in undifferentiated ReNcell VM neural progenitor cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Sox2 in undifferentiated ReNcell VM neural progenitor cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Sox2 in undifferentiated ReNcell VM neural progenitor cells.
Target description
The unconjugated antibody (AB5603) tested on western blot detects Sox2 in whole cell or nuclear extracts as a protein band at 34 kDa
Physical form
Affinity purified
Purified rabbit polyclonal conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage and Stability
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Analysis Note
Control
Undifferentiated ReNcell VM neural progenitor cells
Undifferentiated ReNcell VM neural progenitor cells
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Amanda J Audesse et al.
Aging and cancer, 2(4), 137-159 (2022-10-29)
Glioblastoma (GBM) is an aggressive, age-associated malignant glioma that contains populations of cancer stem cells. These glioma stem cells (GSCs) evade therapeutic interventions and repopulate tumors due to their existence in a slowly cycling quiescent state. Although aging is well
Daniel L Haus et al.
Stem cell research, 13(2), 214-226 (2014-08-02)
Common methods for the generation of human embryonic-derived neural stem cells (hNSCs) result in cells with potentially compromised safety profiles due to maintenance of cells in conditions containing non-human proteins (e.g. in bovine serum or on mouse fibroblast feeders). Additionally
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