8.20171

Bromine

for synthesis

• Synonym(s): Bromine
• CAS Number: 7726-95-6
• Molecular Weight: 159.81
• MDL number: MFCD00010896
• UNSPSC Code: 12352300
• EC Index Number: 231-778-1
• NACRES: NA.22

Properties

• vapor pressure: 233 hPa ( 20 °C)
• Quality Level: 200
• form: liquid
• reaction suitability: reagent type: oxidant
• kinematic viscosity: 0.314 cSt(20 °C)
• bp: 58.8 °C/1013 hPa
• mp: -7.3 °C
• solubility: 35 g/L
• density: 3.12 g/cm³ at 20 °C (liquid)
• storage temp.: 15-25°C
• InChI: 1S/BrH/h1H/p-1
• InChI key: CPELXLSAUQHCOX-UHFFFAOYSA-M

Description

General description

for synthesis

Application

Bromine can be used as an oxidizing agent for the oxidation of:

• Primary alcohols to either aldehydes or esters and secondary alcohols to give ketones.
• Alcohols or diols to tetrahydrofurans in the presence of silver(I) salts.
• Enediol bis-trimethylsilyl ethers to α-diketones.
• Aldehydes to esters in the presence of alcohol solvents and sodium bicarbonate buffer.
• Aliphatic and aromatic thiols to disulfides.

Bromine can also be used along with other co-reactants such as hexamethylphosphoric triamide (HMPA) and bis(tributyltin) oxide (HBD) to selectively oxidize secondary alcohols. However, bromine/nickel carboxylates convert 1,4-diols to γ-butyrolactones by selective oxidation of the primary alcohols.

Analysis Note

Assay (iodometric)≥ 99.0 %AppearanceBrownish-red fuming liquid

Safety Information

• pictograms: GHS05,GHS06,GHS09
• signalword: Danger
• hcodes: H314 - H330 - H400
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class: 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable