684500

Zaprinast - CAS 37762-06-4 - Calbiochem

A cell-permeable, selective inhibitor of cGMP-specific phosphodiesterase (PDE V; IC₅₀ = 450 nM).

• Synonym(s): Zaprinast - CAS 37762-06-4 - Calbiochem, 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948
• Empirical Formula (Hill Notation): C₁₃H₁₃N₅O₂
• CAS Number: 37762-06-4
• Molecular Weight: 271.27
• MDL number: MFCD00214073
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• potency: 450 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: tan to pink
• solubility: DMSO: 25 mg/mL; ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
• InChI key: REZGGXNDEMKIQB-UHFFFAOYSA-N

Description

General description

A cell-permeable, selective inhibitor of cGMP-specific phosphodiesterase (PDE V; IC₅₀ = 450 nM). Inhibits PDE IX at higher concentration (IC₅₀ = 35 µM). Also known to increase cGMP levels in spontaneously hypertensive rat (SHR) plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.

Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC₅₀ = 450 nM). Also known to increase cGMP levels in SHR plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cGMP-specific phosphodiesterase

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.







From Catalog:

Desc. Field- added "cell-permeable"

Other Notes

Fisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med.152, 1605.
Dundore, R.L., et al. 1993. Eur. J. Pharmacol.249, 293.
Pagani, E.D., et al. 1993. Eur. J. Pharmacol.243, 141.
Burns, F., et al. 1992. Biochem. J.283, 487.
Lugnier, C., et al. 1992. Am. J. Physiol.262, H654.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10-13 - German Storage Class 10 to 13