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Key Documents

681725-M

Sigma-Aldrich

WY-14643 - CAS 50892-23-4 - Calbiochem

Synonym(s):

[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I

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About This Item

Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

crystalline solid

color

white

solubility

DMSO: 50 mg/mL

General description

A potent peroxisome proliferator. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands. Inhibits TNF-α induced expression of VCAM-1 in endothelial cells. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.

Biochem/physiol Actions

Peroxisome proliferator-activated receptor 7alpha; (PPARα) ligands

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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H Keller et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(6), 2160-2164 (1993-03-15)
The nuclear hormone receptors called PPARs (peroxisome proliferator-activated receptors alpha, beta, and gamma) regulate the peroxisomal beta-oxidation of fatty acids by induction of the acyl-CoA oxidase gene that encodes the rate-limiting enzyme of the pathway. Gel retardation and cotransfection assays
J D Tugwood et al.
Annals of the New York Academy of Sciences, 804, 252-265 (1996-12-27)
We have been attempting to elucidate the molecular mechanisms through which peroxisome proliferators exert their pleiotropic effects, with particular emphasis on understanding why humans appear unresponsive to these compounds. There is a wealth of data to implicate the peroxisome proliferator-activated
I Issemann et al.
Nature, 347(6294), 645-650 (1990-10-18)
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help
H Keller et al.
Trends in endocrinology and metabolism: TEM, 4(9), 291-296 (1993-11-01)
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily like the steroid, thyroid, or retinoid hormone receptors, which are ligand-activated transcription factors regulating gene expression. PPARs mediate the induction of the enzymes of the peroxisomal and microsomal
N Marx et al.
Circulation, 99(24), 3125-3131 (1999-06-22)
Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member
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