662089-M
UCH-L3 Inhibitor - CAS 30675-13-9 - Calbiochem
Synonym(s):
Ubiquitin C-Terminal Hydrolase L3 Inhibitor, Ubiquitin C-Terminal Esterase L3 Inhibitor, Ubiquitin Thiolesterase L3 Inhibitor, 4,5,6,7-Tetrachloroindan-1,3-dione
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About This Item
General description
A selective and potent inhibitor of ubiquitin C-terminal hydrolase L3 (UCH-L3) (IC50 = 600 nM) that exhibits ~125-fold greater selectivity for UCH-L3 compared to UCH-L1 (IC50 = 75 μM).
We are offering TCID (Cat. No. SML1402) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information. A 1,3-indanedione compound that acts as a selective and potent inhibitor of UCH-L3 (IC50 = 0.6 μM) with ~125-fold greater selectivity over UCH-L1 (IC50 = 75 μM).
Biochem/physiol Actions
UCH-L3
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Yichin Liu et al.
Chemistry & biology, 10(9), 837-846 (2003-10-03)
Neuronal ubiquitin C-terminal hydrolase (UCH-L1) has been linked to Parkinson's disease (PD), the progression of certain nonneuronal tumors, and neuropathic pain. Certain lung tumor-derived cell lines express UCH-L1 but it is not expressed in normal lung tissue, suggesting that this
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