616450
TGF-β1, Human Platelets
Synonym(s):
hTGF-β1, Transforming Growth Factor-β1
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About This Item
UNSPSC Code:
12352202
assay
≥97% (SDS-PAGE)
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
impurities
≤1 EU/μg Endotoxin (EU/ug of TGF-β1)
shipped in
ambient
storage temp.
−20°C
General description
Native transforming growth factor-β1 from human platelets. Promotes apoptosis in resting human B lymphocytes, glioma cells, and trigeminal neurinomal cells.
Native transforming growth factor-β1 from human platelets. Promotes apoptosis in resting human B lymphocytes, glioma cells, and trigerminal neurinomal cells.
Biochem/physiol Actions
ED₅₀ = 40-10 pg/ml as measured by the inhibition of IL-4-dependant proliferation of mouse HT-2 cells using resazurin dye as an indicator of cell proliferation.
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from a sterile-filtered solution of 50 µg BSA/µg TGF-β1, 35% acetonitrile, 0.1% TFA.
Preparation Note
Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following reconstitution, store in the refrigerator (4°C) for short-term storage or freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 months at 4°C or up to 3 months at -20°C..
Reconstitute to a concentration ≥10 µg/ml in sterile 4 mM HCl containing ≥0.1% HSA or BSA.
Other Notes
Lomo, J., et al. 1995. J. Immunol.154, 1634.
Marushige, K. and Marushige, Y. 1995. Anticancer Res.14, 2419.
Bermundez, L.E. 1993. J. Immunol.150, 1838.
Hamilton, J.A., et al. 1993. J. Immunol.150, 1496.
Reilly, J.T., et al. 1993. Br. J. Haematol.83, 58.
Sporn, M.B. and Roberts, A.B. 1993. Growth Factors8, 1.
Marushige, K. and Marushige, Y. 1995. Anticancer Res.14, 2419.
Bermundez, L.E. 1993. J. Immunol.150, 1838.
Hamilton, J.A., et al. 1993. J. Immunol.150, 1496.
Reilly, J.T., et al. 1993. Br. J. Haematol.83, 58.
Sporn, M.B. and Roberts, A.B. 1993. Growth Factors8, 1.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
Certificates of Analysis (COA)
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