603425

Threonine Dehydrogenase Inhibitor, QC1

The Threonine Dehydrogenase Inhibitor, QC1 controls the biological activity of Threonine Dehydrogenase.

• Synonym(s): Threonine Dehydrogenase Inhibitor, QC1, N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
• Empirical Formula (Hill Notation): C₂₃H₁₆F₃N₃O₂S
• CAS Number: 403718-45-6
• Molecular Weight: 455.45
• MDL number: MFCD02649259
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥96% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC₅₀ ~ 0.5 µM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC₅₀ >10 µM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC₅₀ ~3 µM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC₅₀ ~1 mM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Alexander, P.B., et al. 2011. Proc. Natl. Acad. Sci. USA108, 15828.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable