574662

Survivin Inhibitor, YM155

The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.

• Synonym(s): Survivin Inhibitor, YM155, Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
• Empirical Formula (Hill Notation): C₂₀H₁₉BrN₄O₃
• CAS Number: 781661-94-7
• Molecular Weight: 443.29
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• potency: 540 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Cc1n(CC2=NC=CN=C2)C(C3=O)=C([n+]1CCOC)C(C4=C3C=CC=C4)=O.[Br-]
• InChI: 1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
• InChI key: QBIYUDDJPRGKNJ-UHFFFAOYSA-M

Description

General description

A cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC₅₀ = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Interleukin enhancer-binding factor 3 (ILF3/NF110)

Reversible: yes

Secondary Target
Unknown

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Nakamura, N., et al. 2012. Mol. Cell. Proteomics.11, M111.0132434.
Tolcher, A.W., et al. 2008, J. Clin. Oncol.26, 5198.
Nakahara, T., et al. 2007, Cancer Res.67, 8014.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable