InSolution, ≥97%, inhibitor of sirtuin class of histone deacetylase (HDAC) activity
Synonym(s):
InSolution Sirtinol, 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
OK to freeze desiccated (hygroscopic) protect from light
shipped in
wet ice
Storage temp.
2-8°C
General description
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).
Biochem/physiol Actions
Cell permeable: yes
Primary Target ySir2
Product does not compete with ATP.
Reversible: no
Target IC50: 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
Reconstitution
Following initial thaw, aliquot and refrigerate (4°C).
Other Notes
Mai, A., et al. 2005. J. Med. Chem.48, 7789. Grozinger, C.M., et al. 2001. J. Biol. Chem.276, 38837.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
Certificates of Analysis (COA)
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