565791

γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1

The γ-Secretase Inhibitor XXII, Aβ42-Selective, CS-1, also referenced under CAS 1210283-33-2, controls the biological activity of γ-Secretase.

• Synonym(s): γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1, 3,3ʹ-(3,4,5-Trifluorophenyl)methylenebis-(4-hydroxycoumarin)
• Empirical Formula (Hill Notation): C₂₅H₁₃F₃O₆
• CAS Number: 1210283-33-2
• Molecular Weight: 466.36
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable di-coumarin compound that selectively inhibits γ-secretase-mediated production of Aβ42 over Aβ38, Aβ40, and Notch1 both in cell-free APP cleavage assays (IC₅₀ = 0.07, 0.71, 0.31, and 1.77 µM, respectively) and in human and murine cultures (100% blockage of Aβ42 production and no effect against the rest at 30 µM) by altering the S1′ and S3′ pockets within the presenilin substrate binding site via an allosteric, non-substrate-competitive mechanism.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shelton, C.C., et al. 2009. Proc. Natl. Acad. Sci. USA106, 20228.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable