A competitive, selective inhibitor for protein kinase C (IC50 = 10 nM) over protein kinase A (IC50 = 900 nM), Ca2+/calmodulin-dependent protein kinase (IC50 = 17 µM) and phosphorylase protein kinase. Inhibits TPA induced p47 phosphorylation in platelets (IC50 = 700 nM). Also inhibits CD3 downregulation in T cells (IC50 = 500 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target PKC
Product competes with ATP.
Reversible: yes
Target IC50: 10 nM against protein kinase C (PKC); 6.8 nM against GSK-3 in primary adipocytes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Physical form
A 5 mM (500 µg/181 µl) solution of Ro-31-8220 (Cat. No. 557520) in H₂O.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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