Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~65 kDa α- and β-isoforms of the A(PR65) regulatory subunit of PP2A.
Immunogen
Mammalian
a synthetic peptide (DDSLYPIAVLIDE) corresponding to amino acids 7-19 of the mammalian PP2A/A regulatory subunit, conjugated to KLH
Application
Immunoblotting (1:500)
Immunocytochemistry (1:500)
Warning
Toxicity: Standard Handling (A)
Physical form
In 10 mM Tris-HCl, 3 mM glycine, pH 7.5.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Cross-reacts with PR65 from most mammalian species, including human, rat, and mouse. Exhibits minor cross-reactivity with tubulin in whole brain homogenates. Variables associated with assay conditions will dictate the proper working dilution.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme composed of a catalytic, scaffolding, and regulatory subunit. In the heart, PP2A activity is requisite for cardiac excitation-contraction coupling and central in adrenergic signaling. We found that mice deficient in the PP2A
The Journal of biological chemistry, 288(2), 1032-1046 (2012-12-04)
Kinase/phosphatase balance governs cardiac excitability in health and disease. Although detailed mechanisms for cardiac kinase regulation are established, far less is known regarding cardiac protein phosphatase 2A (PP2A) regulation. This is largely due to the complexity of the PP2A holoenzyme
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