539163-M

Proteasome Inhibitor III

The Proteasome Inhibitor III controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): Proteasome Inhibitor III, MG-262, Z-LLL-B(OH)₂
• Empirical Formula (Hill Notation): C₂₅H₄₂BN₃O₆
• CAS Number: 179324-22-2
• Molecular Weight: 491.43
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: white
• solubility: DMSO: 5 mg/mL
• Storage temp.: −20°C
• InChI: 1S/C25H42BN3O6/c1-16(2)12-20(24(31)29-22(26(33)34)14-18(5)6)27-23(30)21(13-17(3)4)28-25(32)35-15-19-10-8-7-9-11-19/h7-11,16-18,20-22,33-34H,12-15H2,1-6H3,(H,27,30)(H,28,32)(H,29,31)/t20-,21-,22-/m0/s1
• Inchi Key: MWKOOGAFELWOCD-FKBYEOEOSA-N

Description

General description

A boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (K_i = 0.03 nM versus 4 nM for MG-132).

Biochem/physiol Actions

Target K_i: 30 pM against proteasome

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Leu-Leu-Leu-B(OH)₂

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Adams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable