5.31621

APT2 Inhibitor, Cpd1

• Synonym(s): APT2 Inhibitor, Cpd1, Lysophosphilipase 2 Inhibitor, LYPLA2 Inhibitor
• Empirical Formula (Hill Notation): C₂₃H₂₂N₂O₄S₂
• CAS Number: 890819-86-0
• Molecular Weight: 454.56
• MDL number: MFCD14808090
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• potency: 510 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: pale orange
• solubility: DMSO: 10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC2=C(C(C=CC=C3)=C3S(C2)(=O)=O)S1)N(CC4)CCN4C5=CC=C(OC)C=C5

Description

General description

A cell permeable acetylpiperazine derivative that acts as a selective and reversible inhibitor of lysophopholipase 2 (LYPLA2; IC₅₀ = 510 nM, K_i = 230 nM) without affecting the activity of LYPLA1 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA2 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).

A cell permeable, selective, and reversisble inhibitor of lysophopholipase 2 (LYPLA2; IC₅₀ = 510 nM, K_i = 230 nM). Does not affect LYPLA1.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
APT2

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Adibekian, A., et al. 2012. J. Am. Chem. Soc.134, 10345.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable