520224

PPACK, Dihydrochloride, Biotinylated

Potent inhibitor of thrombin and tissue plasminogen activator (tPA). Useful for Western blot analyses of Factor VIIa, Factor XIa, thrombin, and tPA.

• Synonym(s): PPACK, Dihydrochloride, Biotinylated, Biotin-X-D-Phe-Pro-Arg-chloromethylketone, 2HCl
• Empirical Formula (Hill Notation): C₄₃H₇₀ClN₁₀O₇S · 2HCl
• Molecular Weight: 979.52
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥80% (HPLC and TLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

Biotin-X-analog of Cat. No. 520222. Specific probe for active serine proteases. Potent inhibitor of thrombin and tissue plasminogen activator (tPA). Useful for Western blot analyses of Factor VIIa, Factor XIa, thrombin, and tPA.

Biotin-X-analog of Cat. No. 520222. Specific probe for active serine proteases. Potent inhibitor of thrombin and tissue plasminogen activator (tPA). Useful for Western blot analyses of Factor VIIa, Factor XIa, thrombin, and tPA.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 110 nM against thrombin

Warning

Toxicity: Standard Handling (A)

Physical form

In 10 mM HCl.

Other Notes

Williams, E.B., et al. 1989. J. Biol. Chem.264, 7536.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable