5.09886

Myristoylated Myr-KFEEERARAKWDT, mP13

• Synonym(s): Myristoylated Myr-KFEEERARAKWDT, mP13, Integrin Signaling inhibitor II, mP13
• Empirical Formula (Hill Notation): C₈₇H₁₃₈N₂₂O₂₄
• Molecular Weight: 1876.16
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: DMSO: 100 mg/mL; water: insoluble
• storage temp.: −70°C

Description

General description

A cell-permeable, myristoylated 13-mer peptide derived from EXE-motif-containing integrin β3 subunit that inhibits talin association with β3. Shown to inhibit both inside-out and outside-in signaling. Blocks all phases of integrin signaling including fibrinogen binding, platelet adhesion, and clot retraction.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Integrin alphaIIbbeta3

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

KFEEERARAKWDT

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shen, B., et al. 2013. Nature503, 131.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable